Take the following steps to have a great start:

1. Add a Datatransform:"DisableEverythingMobile" to Activity:"PreDisplayHarness".
2. In your Datatransform:"DisableEverythingMobile", add the following steps:
   1. When -- pxThread.pxPortal=="YourPortal"   (define your portal, otherwise all portals and harnesses will be affected!!)
   2. Set -- pxRequestor.pxIsMobileClient == false
   3. Set -- pxRequestor.pyIsMobile == false
   4. Set -- pxRequestor.pxIsMobileDevice == false
   5. Set -- pxRequestor.pxDeviceType == "desktop"
3. Disable the following When rules:
   1. When:"pyIsMobilePhone"
   2. When:"pyIsIOS"
4. Now optimize the responsive design of your application.