Most of these operators are being used by the Pega Strategic applications and would like to know why you want to disable them? I would suggest you to know the usage of each operator in your application and take the respective action.
You can take either approach, as the disable operator utility was designed to force everyone to either change the password or disable OOTB operators completely.
Over the time it was released that people were still using the OOTB password which was not safe. So if you move to 7.4 you would anyway have to do. But if you using older version then you can use this utility it will do it for you, than you doing it manually.
So final take is either change password or disable them, as Pega recommend the same.
Let me know if you have any query regarding the utility link I shared.