The Hosts file in Windows is located at the following location: C:\Windows\System32\drivers\etc
Hosts file should be updated (with hostname and ipaddress of endpoint URLs of SOAP Services) on all the Services hosting PRPC application.
The hosts file is one of several system facilities that assists in addressing network nodes in a computer network. It is a common part of an operating system's Internet Protocol (IP) implementation, and serves the function of translating human-friendly hostnames into numeric protocol addresses, called IP addresses, that identify and locate a host in an IP network.
Can you please elborate what you actually intend by local and global? Are you trying to access the hosts file over a network?