One issue you may run into is PRPC generating URL's based on how it was accessed from the F5. In PRPC the pxThread page will have properties used in stream processing that reflect the https://www.pegahosturl/prweb .
Chris, Appreciate your time and thorough feedback in highlighting the challenges. Yes we ran into these issues and later corrected our configurations on both set context URI and prconfig to make the solution work.
However we would also like to get advised if this would be a preferred and recommended solution.