One of the main suspects is the antivirus. We always recommend that openspan is whitelisted, however, the main recommendation here is that you update your version of the software, as openspan 5.2 is no longer supported.
It is probably the Anti-Virus. Do you know what AntiVirus is being used? Perhaps you don't need to disable it completely but create exceptions for OpenSpan or disable specific functions, (for example, disable exploit modules) etc.
As my colleague has also mentioned, OpenSpan 5.2 is a very old version and is not supported anymore, so if this is a product issue then there is not many paths that you can take to move forward. Your best path is to investigate the environment further and narrow down the component that is stopping OpenSpan.