With a new version of windows 10, you will need to update the PRS version to 19.1.50 or .51 to account for new security settings with Windows. If you have access to Pega community, you can navigate to the Robotic Process Automation page to request the newer version.
You can click on Pega Robotic Automation 19.1 to see each build version and the notes about it. This is not where you download them to be clear. When you download from the Digital Delivery Portal, you should get an option to select a specific build.
I just found out that MS put quietly pushed out another security update. The easiest means to get around that, if you cannot get access to 19.1.50+ is to delete the current ACME web adapter from the ACMESearch project, and add back a Universal Web Adapter, assuming you have Chrome or Firefox. This is a temporary workaround until a fix can be found.
You will need to add training.openspan.com with 'contains' as the Regex rule to the accepted domains on the UWA properties window.